Antihistamines

Allergies and histamine

Your body can become hypersensitive to things in its environment, such as foods, plants, animals, and medications. An allergen is something to which you are allergic.

When the body is exposed to allergens it releases histamine, a chemical that is an important part of your body’s immune response. Histamine makes you sneeze, makes your nose run, and makes your eyes and skin itch, become red and swell up. In a way, it is trying to get you to sneeze out or scratch away the allergen.

Treating allergies and allergic reactions with antihistamines

Antihistamines are medicines that act by blocking the body's response to histamine in different parts of the body. This reduces the severity of the reaction and eases the symptoms of allergy.

Antihistamines are commonly used to treat a number of conditions related to allergies and hypersensitivities such as:

• hay fever (allergic rhinitis)

• hives (urticaria)

• allergic conjunctivitis

• eczema (dermatitis)

• asthma

• reactions to bites and stings

Some antihistamines block histamine in the stomach and reduce acid production, and are therefore used to treat heartburn and indigestion. These antihistamines are different from those used to treat allergies.

Oral antihistamines can be used to treat all of the symptoms of an allergic reaction. Others come as eye drops or nasal sprays, for treating specific symptoms only. Some oral antihistamines may have a sedative effect, but others are non-sedating or non-drowsy.

Side effects of antihistamines

Some people get side effects from oral antihistamines such as:

• tiredness

• drowsiness

• headache

• dry mouth

• upset stomach

They usually don't last long.

If you use antihistamines you should be careful when operating machinery, such as driving a car. Even non-sedating antihistamines can make some people drowsy.

You should talk to a pharmacist or doctor before taking an antihistamine if you:

• have kidney or liver disease

• are a woman who is pregnant or breastfeeding

• are a man with prostate enlargement

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